I'm on 100 mg of Zoloft generic (Sertraline) for OCD. I am still having persistent OCD symptoms at 100 mg. I would say maybe a 25% reduction (at best). I've tried every SSRI there is available to me from Prozac, Paxil, Lexapro, Celexa, Buspar, Luvox, and now Zoloft. Is there any point to even continuing a search for a medicine that can help my OCD if none of these things have really helped. Prozac dose was 20 mg, Paxil was 10 mg, Luvox was up to 300 mg, Lexapro was 20 mg, Celexa was 20 mg, and Buspar was 60 mg(20mg 3x/Day). Every SSRI makes me feel tired, unmotivated, and rather anhedonic. What can I possibly do at this point to improve my condition? I have discussed this with my doctor and counselor (psychotherapist) and they don't know what to do anymore. What is feasible having tried all these things? For SNRI's Effexor XR 300 mg, Pristiq 50 mg, and I didn't like those either. I tried Abilify 15 mg, Seroquel 300 mg (XR form), Risperidone (Up to 2.5 mg a day), Viibryd 40 mg, Prazosin 20 mg, and Wellbutrin IR (75 mg 2x/Day).